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Celebrex 200mg:

Indications for use: Celebrex is recommended for the symptomatic therapy of the pain and inflammatory symptoms in patients with osteoarthritis and rheumatoid arthritis.

Pharmacological action: Celebrex is the NSAID and specific cyclooxygenase-2(COX-2) inhibitor. COX-2 is induced in response to the inflammatory process. It causes the synthesis and accumulation of the inflammatory prostanoids, mostly prostaglandin E2 that causes the inflammation, edema and pain. The anti-inflammatory effect of the drug is realized due to the inflammatory prostanoids formation blocking with the help of COX-2 inhibition. The therapeutic concentrations of Celebrex in the human body do not inhibit the COX-1 and thus do not have any effect to the prostanoids, synthesized thanks to the activation of COX-1, and do not interfere into the normal physical processes related to COX-1 in the tissues, especially in the stomach, bowels and platelets. It means the absence of the side effects, related to COX-1 that is gastric ulcers and duodenum ulcers, serious complications in the upper gastrointestinal tract such as bleeding or perforation, and the absence of the inhibition of the COX-2 dependant platelets aggregation.

Pharmacokinetics: In case of the drug intake before meals Celebrex 200mg is well absorbed. Cmax in blood plasma is reached in 2-3 hours. The bioactivity of the drug is 99% (in case of capsules administration). The intake of Buy Celebrex Online together with food makes the drug absorption slower. In this case the Cmax in blood plasma is reached in 6-7 hours. Plasma protein binding doesn't depend on the dose of the drug and as a rule is about 97%. Buy Celebrex Online is excreted through the liver and less than 1% of the dose administrated is excreted unchanged with the urine. In case of the repeated intake T1/2 is 8-12 hours and clearance is about 500 ml per minute.

Dosage and method of application: The daily dose of Celebrex recommended to adult patients is 200 mg for 1 or 2 administrations. If necessary the dose of 200 mg twice for 24 hours can be prescribed. In case of rheumatoid arthritis the total daily dose of 200-400 mg for two intakes is recommended. For the aged patients or patients with moderate compromised liver function it is better to start the Buy Celebrex treatment with the minimum recommended dose.

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Contraindications:

Celebrex is not recommended to the patients with allergies such as urticaria or bronchospasm, related to the acetylsalicylic acid or other NSAIDs intake. It cannot be prescribed to the pregnant women during their III pregnancy trimester or to the nursing mothers. Buy Celebrex therapy cannot be administered to the patients with hypersensitivity to the sulfonamides or to some of the Celebrex components. Buy Celebrex 200mg is the prescription drug, as a rule recommended for the symptomatic therapy. Don't take Buy Celebrex without consulting your doctor before.

Side-Effects:

Celebrex treatment can cause some side effects on the digestive system, such as abdominal pain, diarrhea, dyspepsia, flatulence or nausea, and rarely constipation, eructation, gastritis, stomatitis, vomiting or increased activity of AST and ALT. It can also affect the central nervous system and peripheral nervous system and cause headache, dizziness, insomnia, blurred vision, anxiety, depression or ataxia. It also has some side effects related to the respiratory system, such as pharyngitis, rhinitis, sinusitis or infections of upper respiratory tract. Sometimes the dermatological reactions such as rash, itching, alopecia and photosensitivity are observed.

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